Flow Giese reaction using cyanoborohydride as a radical mediator

• Takahide Fukuyama,
• Takuji Kawamoto,
• Mikako Kobayashi and
• Ilhyong Ryu

Beilstein J. Org. Chem. 2013, 9, 1791–1796, doi:10.3762/bjoc.9.208

• 70 °C in combination with a residence time of 10–15 minutes gave good yields of the desired addition products. Keywords: continuous flow system; cyanoborohydride; flow chemistry; iodoalkanes; microreactor; tin-free Giese reaction; Introduction Organo halides are among the most useful precursors to